Program 4: (CT) Clinical Translation

Application of both biologically and clinically relevant animal models for pre-clinical trials based on technologies and products developed in CNRM, to inform the design and execution of controlled clinical trials.
Theme 1: Musculoskeletal Regeneration
Sub-Project CT.1.1: YUNG, Patrick Shu-Hang (CUHK), LUI, Pauline Po-Yee (CUHK) and LEE, Wayne Yuk-Wai (CUHK)

Prof. Yung is a world recognized leader in the field of orthopaedic sports medicine, with particular contributions to arthroscopy and the advancement of regenerative therapies in orthopaedics and traumatology. In addition to being a keen researcher and educator, he is also committed to medical service for amateur and professional sport communities in Hong Kong, China, & overseas. His research focus is on knee, shoulder, ankle and hip sports injuries. He has established a well-organized clinical trials infrastructure at CUHK which will enable the translation of reparative technologies developed in CNRM to clinical application. The current set-up, which is focused on osteoarthritis and anterior cruciate ligament and rotator cuff repair, will be further adopted for other neuromusculoskeletal clinical trials, specifically those involving mesenchymal stem cells, biologics and biomaterials, which may be prepared using the facilities at the soon-to-be-completed CUHK GMP facility.

Theme 1: Musculoskeletal Regeneration
Sub-Project CT.1.2: SEJERSEN, Thomas (KI) and Von Walden, Ferdinand (KI)

Dr. Sejersen will bring his extensive expertise in hereditary neuromuscular disorders (NMDs) into the CNRM. NMDs affect any component of the motor unit. The exact disease-causing mutations and specific functional consequences are still largely unknown, and this lack of knowledge results in insufficient diagnostic and therapeutic tools, as well as clinical care guidelines. By collaborating with other members of our InnoHK centre, Dr. Sejersen will contribute to improving the genetic diagnosis of patients with NMD and associated cardiomyopathies, gain deeper functional insight into pathophysiological events caused by disease causing gene variants, improve bone health and muscle regeneration in muscular dystrophies, and developing updated care guidelines for NMDs.

Theme 1: Musculoskeletal Regeneration
Sub-Project CT.1.3: TUAN, Rocky S. (CUHK), LI, Zhong Alan (CUHK)

A well-established and highly recognized investigator in stem cells, developmental biology, biomaterials, tissue engineering, and regenerative medicine, Prof. Tuan brings to CNRM his considerable experience in biomedical research and consortial team management. In addition to his major contributions to skeletal tissue engineering, nano- biomaterials, and molecular stem cell derivation and differentiation, Prof. Tuan’s recent innovative nerve engineering work (Biomaterials, 2019) combines mesenchymal stem cells, their paracrine signaling, and the application of an electrospun aligned nanofibrous biomaterial scaffold to repair degenerated peripheral nerve, representing a significant strength of the CNRM. Additional work has also uncovered the bioactivities of cell-derived extracellular vesicles derived from mesenchymal stem cells and their potential therapeutic applications.