Program 3: Cellular and Molecular Mechanisms

Investigate and analyze the cellular and molecular mechanisms that mediate the tissue- and microenvironment-specific responses of cells and their optimization
Theme 2: Epigenetics and Energy Metabolism
PI: WAN, Chao, Co-I: LING, Samuel Ka-Kin

The Wan laboratory has extensive experience in molecular and cellular mechanisms of the oxygen sensing and growth factor pathways in skeletal development, degeneration and regeneration, and discovery of novel therapies for skeletal repair or regeneration. His CNRM project will target the energy metabolism pathway to investigate the precise conditions controlling the fate of chondroprogenitors for the design of 3D bioprinting- based engineering of cartilage that prevents chondrocyte hypertrophy both in vitro and in vivo. He will work with Prof. Ling Ka-kin (Co-I) to explore a phase 1 clinical trial using the procedure established in this study.

Theme 2: Epigenetics and Energy Metabolism
PI: WANG, Huating, Co-I: WONG, Ronald Man-Yeung

Dr. Wang’s laboratory has longstanding interest in studying gene regulatory mechanisms using skeletal muscle cells and cancer cells as model systems. Current studies focus on the functional roles of non-coding RNAs in regulating gene expression in skeletal muscle stem cells and muscle regeneration. Her CNRM project will study how histone- alteration changes in skeletal muscle tissue drive remodeling of gene enhancers and muscle stem cell niche environment, and to characterize changes of transcriptome, chromatin accessibility and histone modifications in muscle stem cells from aging mouse. Additional focus will be on how caloric restriction and exercise may improve aging muscle stem cell function through modulating the above epigenetic hallmarks in mouse.