Publications
Zheyuan Zhou, Fengjie Zhang, Chao Wan* Biomechanically inspired composite hydrogel bioink enhances engineered cartilage formation. International Journal of Bioprinting, 2025:5230. 2025
Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen, Yeelo Cheung, Yu Zhao, Ting Xie, Bénédicte Chazaud, Hao Sun*, Huating Wang* Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy Mouse Through YY1-CCL5 axis. Nature Communications, 2025,16(1):1324. 2025
Ha TY, Chan SW, Wang Z, Law PWN, Miu KK, Lu G, Chan WY*.SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis. Cell Mol Life Sci. 2025 Mar 2;82(1):99. 2025
Wang R, Qian Y, Guo X, Song F, Xiong Z, Cai S, Bian X, WongMH, Cao Q, Cheng L, Lu G*, Leung KS. STModule: identifying tissue modules to uncover spatial components and characteristics of transcriptomic landscapes Genome Med. 2025 Mar 3;17(1):18. 2025
Xuanchen Liu, Mo Wang, Bin Xu, Xue Ma, Yangzi Jiang, Hai Huang, Zengzeng Shi, Hao Wu, Zhigang Wu, Shuo Guo, Jungang Zhao, Jian Zhao, Xiaokang Li, Li Liang, Zheng Guo, Lei Shi*, Chao Sun*, Ning Wang* Discovery and identification of semaphorin 4D as a bioindicator of high fracture incidence in type 2 diabetic mice with glucose control Journal of Advanced Research. S2090-1232(25)00174-2. 2025
Fengjie Zhang, Yichen Zhao, Qiling He, Lonnie Schneider, Jianghua Zhang, Chao Wan* Lysosomal cathepsin D regulates bone turnover through distinct mode of actions of the autophagy pathways in osteoblasts and osteoclasts. bioRxiv. 2025
- Bangheng Liu, Zhen Zhang, Yulei Mu, Liang Ma, Huiqun Zhou, and Dong-An Wang* Biophysical-inspired Interpenetrated Fibrillar and Reticular Collagen Scaffold with Vascular Endothelial Cell Membrane Incorporation for Guided In Situ Spleen Tissue Regeneration, Advanced Materials, (2025), 2501574. 2025
Liu Y, Zhou Z, Lu G, Zhang X, Shi D, Tong L, Chen D, Tuan RS*, Li ZA.*, Musculoskeletal organoids: An emerging toolkit for establishing personalized models of musculoskeletal disorders and developing regenerative therapies Acta Biomater. 2025 Jun 15;200:158-186. Epub 2025
Ka Yu Carissa Kwan, Ke Li, Yu Yang Wang, Wai Yi Tse, Chung Yan Tong, Xu Zhang, Dan Michelle Wang, Dai Fei Elmer Ker* The Characterization of Serum-Free Media on Human Mesenchymal Stem Cell Fibrochondrogenesis/ Bioengineering 2025, 12(5), 546. 2025
Yanmei Chen, Yang Xu, Jiawei Cai, Marianne Lauwers, Liwei Xiang, Yali Zheng, Hua Chu, Xianglong Chen, Dai Fei Elmer Ker, Cheng Zhang*, Dan Michelle Wang*, Zhiyong Zhang* Automated and Enclosed Three-Dimensional Biofabrication System for Mesenchymal Stem Cell Culture to Enhance Diabetic Wound Healing / Biomaterials research, 29, 0205.. 2025
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang Optimizing Biophysical Properties of Cellular Niches to Enhance Stem Cell-derived Extracellular Vesicle Function in Musculoskeletal Regeneration / BMEMat pg. e70012. 2025
Christy Wing Tung Wong, Joyce Zhi Xuen Lee, Anna Jaeschke, Sammi Sze Ying Nga, Kwok Keung Lit, Ho-Ying Wan, Caroline Kniebs, Dai Fei Elmer Ker, Rocky S. Tuan, Anna Blocki , Lung cancer intravasation-on-a-chip: Visualization and machine learning-assisted automatic automatic quantification; Bioactive Materials 51 (2025) 858–875. 2025
Y. Liu, Z. Zhou, G. Lu, X. Zhang, D. Shi, L.Tong, D. Chen*, R.S. Tuan*, Z.A. Li* Musculoskeletal organoids: An emerging toolkit for establishing personalized models of musculoskeletal disorders and developing regenerative therapies. 2025
Yangzi JIANG*, Development of New Therapies for Early Osteoarthritis: From Pathology to Solutions AO Orthopaedic Research Summit, 2025 June 18; EO.8.S8, 13:45-15:15. 2025
Christy Wing Tung Wong, Joyce Zhi Xuen Lee, Anna Jaeschke, Sammi Sze Ying Ng, Kwok Keung Lit, Ho-Ying Wan, Caroline Kniebs, Dai Fei Elmer Ker, Rocky S. Tuan, Anna Blocki*, “Lung cancer intravasation-on-a-chip: Visualization and machine learning-assisted automatic quantification” Bioactive Materials, Volume 51, September 2025, Pages 858-875. 2025
Malicdan MCV, Allamand V, Durbeej M, Delgado-Vega AM, Sejersen T, Nordgren A, Torta F, Silver DL*, SPNS1 variants cause multi-organ disease and implicate lysophospholipid transport as critical for mTOR-regulated lipid homeostasis. J Clin Invest.” 2025 Jul 3:e193099. 2025
Yang Li, Chuhan Li, Qin Zhou, Xingyuan Liu, Yulong Qiao, Ting Xie, Hao Sun, Michael Tim-Yun Ong, Huating Wang*, Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia”. Nature Communications, 2025, 16(1): 6207. 2025
Zhen Zhang, Ye Huang, Xu Hu, Yulei Mu, Huiqun Zhou, Liang Ma, Bangheng Liu, Hang Yao*, Xieyuan Jiang*, Dong-An Wang*, In situ implantation of type II collagen-based double-layer scaffolds for Articular Osteochondral Regeneration comprising hyaline cartilage and vascularized subchondral bones”, Bioactive Materials, 50 (2025) 8: 364-381. 2025
- Huang S, Rao Y, Zhou M, Blocki A*, Ker DFE*, Tuan RS* and Wang D* (2024) Engineering an extracellular matrix-functionalized, load-bearing tendon substitute for effective repair of large-to-massive tendon defects. Bioactive Materials., 36:221-237.
- Simpson A, Sejersen T*, Ekström A-B, Kroksmark A-K, Kwiatkowska M, Graham S, Ganz M, Gerlow K(2024) Healthcare Resource Utilisation and Direct Medical Cost for Individuals with 5q Spinal Muscular Atrophy in Sweden. Eur J Health Economics.
- He L, Sun H*, Wang H* (2024) 3D organization of enhancers in MuSCs. Current Topics in Developmental Biology.,ISSN 0070-2153.
- Zhang X,Ker DFE* ,Tuan RS*, Wang C, Wang D, Yung PSH (2024) Optimized design of an enthesis-mimicking suture anchor-tendon hybrid graft for mechanically robust bone-tendon repair. Acta Biomaterialia., 176:277-292.
- Lee YW, Kot CH, Chen SC, Lui PPY* (2024) Spatial Transcriptomic Revealed Potential Role of Exogeneous Immune Cells in Extracellular Matrix Degradation and PI3K-AKT Pathway in Angiogenesis in Rotator Cuff Tendinopathy. In Proceedings of The 70th Annual Meeting of the Orthopaedic Research Society, Long Beach Convention Center, Long Beach, CA, USA.
- Lee YW, Kot CH, Chen SC, Wong CM, Lui PPY* (2024) Obesity Induced Tendinopathy-like Histopathological Changes in Tendon and Maintained TDSCs in a Healing State with Low Regenerative Capacity. In Proceedings of The 70th Annual Meeting of the Orthopaedic Research Society, Long Beach Convention Center, Long Beach, CA, USA.
- Ma Z, Lee YW, Kot CH, Lui PPY* (2024) FABP4 as a novel target for the treatment of tendinopathy. In Proceedings of The 70th Annual Meeting of the Orthopaedic Research Society, Long Beach Convention Center, Long Beach, CA, USA.
- He X, Gong G, Chen M, Zhang H, Zhang Y, Richardson JJ, Chan WY , He Y, Guo J* (2024) Metal-Phenolic Nanocloaks on Cancer Cells Potentiate STING Pathway Activation for Synergistic Cancer Immunotherapy. Angewandte Chemie International Edition., 63(12):e202314501.
- Li Y, Li C, Sun Q, Chen F, Cheung Y, Zhao Y, Xie T, Chazaud B, Sun H*, Wang H* (2024) Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy through YY1-CCL5 Axis.BioRxiv. Nature Communications., bioRxiv 2024.01.13.575317.
- Zhou Z, Liu J, Xiong T, Liu Y, Tuan RS*, Li ZA* (2024) Engineering Innervated Musculoskeletal Tissues for Regenerative Orthopedics and Disease Modeling. Small., e2310614.
- Yao HY, Zhang F, Wan C*(2023) Inhibition of TRPML1 Alleviates Osteoarthritis Progression by Suppressing Mitochondrial Calcium Overload. 13th International Symposium of Stem Cell and Regenerative Medicine, Guangzhou, China.
- Huang S, Rao Y, Ju AL, Ker DFE, Blocki A*,Wang D*, Tuan RS*. (2023) Non-collagenous proteins, rather than the collagens, are key biochemical factors that mediate tenogenic bioactivity of tendon extracellular matrix. Acta Biomater., 176:99-115.
- He Z, Chen X, Liu G, Li Y, Yang F, Sun H*, Wang H* (2023) Sugt1 loss in skeletal muscle stem cells impairs muscle regeneration and causes premature muscle aging. Life Medicine, Volume 2, Issue 4.
- Sun Q, Zhou Q, Qiao Y, Sun H*, Wang H* (2023) Pervasive RNA Binding Protein Enrichment on TAD Boundaries Regulates TAD Organization. BioRxiv., bioRxiv 2023.11.22.567635.
- Chen SC, Deng J, Hu K, Fu CHY, Ong TY, Lau LCM, Lui PPY*,Yung PSH (2023) Effects of pulsed electromagnetic field (PEMF) for the promotion of cartilage regeneration and pain relief in patients with early knee osteoarthritis – A double-blinded placebo-controlled randomized clinical trial. In Proceedings of The 43rd Annual Congress of The Hong Kong Orthopaedic Association,Hong Kong SAR, China.
- Liang Z, Lui PPY*,Yung PSH (2023) Effect of high-fat diet-induced obesity on collagenase-induced tendon injury. In Proceedings of The 43rd Annual Congress of The Hong Kong Orthopaedic Association,Hong Kong SAR, China.
- Lee YW, Kot CH, Lui PPY* (2023) Effect of high fat diet on the histopathology and inflammation of Achilles tendons in Mice. In Proceedings of The 43rd Annual Congress of The Hong Kong Orthopaedic Association, Hong Kong SAR, China.
- Ma Z, Lee YW, Kot CH, Chen SC, Lui PPY* (2023) Overexpression of FABP4 in clinical samples and animal model of tendinopathy is associated with excessive tendon inflammation. In Proceedings of The 43rd Annual Congress of The Hong Kong Orthopaedic Association,Hong Kong SAR, China.
- Rolińska K, Bakhshi H, Balk M, Blocki A*, Panwar A, Puchalski M, Wojasinski M, and Mazurek-Budzynska M(2023) Electrospun Poly(carbonate-urea-urethane)s Nonwovens with Shape-Memory Properties as a Potential Biomaterial. ACS Biomater. Sci. Eng., 9(12):6683-6697.
- Kwan KYC, Ng KWK, Rao Y, Zhu C, Qi S, Ker DFE*, Tuan RS*, and Wang D* (2023) Effect of Aging on Tendon Biology, Biomechanics and Implications for Treatment Approaches. International Journal of Molecular Sciences., 24(20):15183.
- Zhou ZY, Zhang F, Wan C* (2023) Chemical modified composite hydrogels enhance engineered cartilage formation. TERMIS-AP 2023 Conference, Hong Kong SAR.
- Donderwinkel I, Tuan RS, Cameron NR, Frith JE*(2023) A systematic investigation of the effects of TGF-ß3 and mechanical stimulation on tenogenic differentiation of mesenchymal stromal cells in a poly(ethylene glycol)/gelatin-based hydrogel. J Orthop Translat., 43:1-13.
- Lee YW, Wong CM, Xu JJ, Lui PPY*, Yung PSH (2023) Protein X Knockout on Tendon-derived Stem Cell Functions and Histopathology of Tendon. In Proceedings of Tissue Engineering and Regenerative Medicine International Society Asia-Pacific Chapter (TERMIS-AP) Conference 2023, Hong Kong Science Park, Hong Kong SAR, China.
- Li X, Chan YT, Jiang Y* (2023) Development of an image processing software for quantification of histological calcification staining images. PLoS One., 18(10):e0286626.
- Siu WS, Ma H, Ko CH, Shiu HT, Cheng W, Lee YW, Kot CH, Leung PC, Lui PPY* (2023) Rat plantar fascia stem / progenitor cells showed lower expression of ligament markers and higher pro-inflammatory cytokines after intensive mechanical loading or interleukin-1ß treatment in vitro. Cells., 12(18): 2222.
- Chan WY* , Lu G, Su X, Wang L, Leung CK, Zhou J, Xiong Z, Wang W, Liu H(2023) Neuroprotective Effects of Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Extracellular Vesicles in Ischemic Stroke Models. Biomedicines., 11(9):2550.
- Zhang Y, Zhao J, Chen X, Lyu K, Ding Y, Sun H*, Kwok CK*, Wang H* (2023) DHX36 binding induces RNA structure remodeling and regulates RNA abundance via m6A/YTHDF1. Nature Communications., bioRxiv 2023.08.06.551902.
- Zhang S, Yang F, Huang Y, He L, Li Y, Wan YCE, Ding Y, Chan KM, Xie T, Sun H* and Wang H* (2023) ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression. Nature Communications., 14:4978.
- Wang BYH, Hsiao AWT, Shiu HT, Wong N, Wang AYF, Lee CW*, Lee OKS*, Lee WYW* (2023) Mesenchymal stem cells alleviate dexamethasone-induced muscle atrophy in mice and the involvement of ERK1/2 signalling pathway. Stem Cell Research & Therapy., 14(1):195.
- Sun J, Chan YZ, Ho KKW, Zhang L, Biane L, Jiang YZ*,Tuan RS* (2023) “Slow walk” mimetic tensile loading maintains human meniscus tissue resident progenitor cells homeostasis in photocrosslinked gelatin hydrogel. Bioactive Materials., 25:256-272.
- Jiang Y*,Tuan RS*. (2023) Bioactivity of human adult stem cells and functional relevance of stem cell-derived extracellular matrix in chondrogenesis. Stem Cell Res Ther.,14(1):160.
- BLOCKI A* , WanN HY, Chen JCH, Xiao Q, Wong CW, Yang B, Tuan RS , Cao B, Susan K. N, HO YP, RAGHUNATH M, Roger D K (2023) Stabilization and Improved Functionality of Three-dimensional Perfusable Microvascular Networks in Microfluidic Devices under Macromolecular Crowding. Biomater Res., 27(1):32.
- Qiao Y, Sun Q, Chen X, He L, Wang D, Su R, Xue Y, Sun H, Wang H* (2023) Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export. Elife., 12:e82703.
- Li K, Zhang X, Ker DFE*,Tuan RS, Wang D (2023) Synergistic effects of growth factor-based serum-free medium and tendon-like substrate topography on tenogenesis of mesenchymal stem cells. Biomaterials Advances., 146:213316.
- Li K, Zhang X, Ker DFE* ,Wang D (2023) Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration. Journal of Visualized Experiments., 146:213316.
- Zhao Y, Ding Y, He L, Zhou Q, Chen X, Li Y, Alfonsi MV, Wu Z, Sun H* and Wang H* (2023) Multiscale 3D Genome Reorganization during Skeletal Muscle Stem Cell Lineage Progression and Muscle Aging. SCIENCE ADVANCES., 9(7):eabo1360.
- Cao M, Yao S, Zhu X, Ong MTY, Jiang Y*, Yung PSH*(2023) Doxycycline Promotes Graft Healing and Attenuates Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Reconstruction in a Rat Model. Am J Sports Med., 51(2):461-475.
- Ker DFE*, Wang D, Zhang X, Ng KW, Rao Y, Wang C, Gharaibeh B, Lin S, Abrams G, Safran M, Cheung E, Campbell P, Lee Weiss, Yang YP*(2022) Growth and Differentiation Factor-7 (GDF-7) Immobilized, Mechanically Strong Quadrol-Hexamethylene Diisocyanate-Methacrylic Anhydride (QHM) Polyurethane Polymer for Tendon Repair and Regeneration. Acta Biomaterialia., 154:108–122.
- Ang ACH, Wong D, Lui PPY* . (2022) Increased Risk of Concomitant Meniscal Injuries in Adolescents With Elevated Body Mass Index After Anterior Cruciate Ligament Tear: A Systematic Review. Arthroscopy., 38(12):3209-3221.
- Dehghan-Baniani D*, Mehrjou B*, Chu PK*, Lee WYW* , Hongkai Wu* (2022) Recent Advances in “Functional Engineering of Articular Cartilage Zones by Polymeric Biomaterials Mediated with Physical, Mechanical, and Biological/Chemical Cues”. Advanced Healthcare Materials.,2202581.
- Cheng CT, Ker DFE*,Wang D, Lee OKS, Wang H* (2022) Application of neural networks on in vitro-generated Raman spectra for label-free, ex vivo skeletal muscle detection. Measurement. Volume 204., 112172.
- Li ZA , Shang J, Xiang S, Li EN, Yagi H, Riewruja K, Lin H*, Tuan RS* (2022) Articular Tissue-Mimicking Organoids Derived from Mesenchymal Stem Cells and Induced Pluripotent Stem Cells.Organoids., 1(2):135-148.
- Zhang X, Wang Z, Ling SKK, Ker DEF*, Tuan RS, Wang Dan, and Yung PSH (2022) Clinical Perspectives for Repairing Rotator Cuff Injuries with Multi-Tissue Regenerative Approaches. Journal of Orthopaedic Translation., 36:91-108.
- Cao M, Ong MTY, Jiang Y*, Tuan RS, Yung PSH, (2022) Role of synovial lymphatic function in osteoarthritis. Osteoarthritis Cartilage., S1063-4584(22)00719-1.
- Shao JF, Jiang Y, Fang ZY* (2022) Editorial: Single cell intelligence and tissue engineering. Front. Bioeng. Biotechnol., 10:1019929.
- So KKH, Huang Y, Zhang S, Qiao Y, He L, Li Y, Chen X, Sham MH, Sun H*, Wang H* (2022) seRNA PAM controls skeletal muscle satellite cell proliferation and aging through trans regulation of Timp2 expression synergistically with Ddx5 Aging Cell., 21(8):e13673.
- Lui PPY*, Leung YT. (2022) Practical Considerations for Translating Mesenchymal Stromal Cell-Derived Extracellular Vesicles from Bench to Bed. Pharmaceutics., 14(8):1684.
- Rao Y, Zhu C, Suen HC, Huang S, Jinyue Liao, Ker DFE, Tuan RS*, Wang D* (2022)Tenogenic induction of human adipose-derived stem cells by soluble tendon extracellular matrix: composition and transcriptomic analyses.Stem Cell Research & Therapy.,13:380.
- Chen X, Xue G, Zhao J, Zhang Y, Zhang S, Wang W, Li Y, Yuan J, He L, Chan CY, Liu Y, Chen W, Zhao Y, Hu P, Sun H*, Kwok CK* and Wang H* (2022) Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5 UTR rG4 unwinding and Anp32e translation. Cell Reports 39., 110927